Search results for "HUMAN TISSUES"
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Contribution to the investigation of dynamic responses of human tissues under high velocity impacts using finite element modeling
2022
Thoracic injuries happen frequently in various frameworks of high velocity impact biomechanics. Rib fractures and lung injuries are the most common hard and soft tissue injuries in human thorax. This thesis aims to contribute to the investigation of dynamic responses of human tissues especially ribs and soft tissues under high velocity impacts using finite element modeling. Firstly, a novel strain-rate-dependent elasto-hydrodynamic constitutive law of the synthetic polymer Styrene-Ethylene-Butylene-Styrene (SEBS) gel was proposed and implemented as a user material subroutine in Radioss (Altair Hyperworks) to interpret dynamic behaviors of SEBS gel under various loading configurations. Numer…
iGEMS : an integrated model for identification of alternative exon usage events
2016
DNA microarrays and RNAseq are complementary methods for studying RNA molecules. Current computational methods to determine alternative exon usage (AEU) using such data require impractical visual inspection and still yield high false-positive rates. Integrated Gene and Exon Model of Splicing (iGEMS) adapts a gene-level residuals model with a gene size adjusted false discovery rate and exon-level analysis to circumvent these limitations. iGEMS was applied to two new DNA microarray datasets, including the high coverage Human Transcriptome Arrays 2.0 and performance was validated using RT-qPCR. First, AEU was studied in adipocytes treated with (n = 9) or without (n = 8) the anti-diabetes drug,…